Researchers' results, which show that creams with vitamin A significantly reduces wrinkles, has been published in the medical journal Archives of Dermatology. Cream was applied to 23 individuals who were all over 87 years old. Subjects used the cream on one forearm for 24 weeks, after which the researchers compared the forearms.

Skin samples were taken before and after the trial, and the researchers found that skin which was applied with anti-wrinkle cream was healthier and healed faster than the skin which did not have the anti aging cream applied.
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